{"id":13263,"date":"2015-03-28T10:58:40","date_gmt":"2015-03-27T23:58:40","guid":{"rendered":"http:\/\/www.poliohealth.org.au\/?page_id=13263"},"modified":"2017-09-15T14:59:46","modified_gmt":"2017-09-15T04:59:46","slug":"post-polio-research-papers-sorted-by-category","status":"publish","type":"page","link":"https:\/\/www.poliohealth.org.au\/research-sorted-by-category\/","title":{"rendered":"Post-Polio Research Papers – Sorted by Category"},"content":{"rendered":"
Title: <\/span>Cancer risk in a cohort of polio survivors Abstract: <\/span>Poliomyelitis has hypothetically been associated with an increased risk of central nervous system (CNS) tumors. The present study was performed to examine not only the risk of CNS tumors but also the overall risk of cancer among a cohort of 5,883 polio patients. Patients diagnosed with acute poliomyelitis in the Danish capital, Copenhagen, between 1919 and 1954 were identified and followed with respect to cancer. Conclusions: <\/span><\/p>\n Outcome of Research: <\/span>More research required<\/p>\n Comments<\/span> (if any)<\/span>:<\/span> The full text of this paper has been generously made available by the publisher.<\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> Click here to view full text or to download<\/a><\/p>\n Title: <\/span>Patient and Clinician Reported Outcomes and Experiences Following Advanced Tele-Rehabilitation Assessments Conducted in Rural Alberta Abstract: <\/span>Research Objectives Conclusions: <\/span>Conclusions Outcome of Research: <\/span>More research required<\/p>\n Comments<\/span> (if any)<\/span>:<\/span> Paid subscription required to view or download full text.<\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> Click here to view Abstract<\/a><\/p>\n Title: <\/span>Increased cerebral integrity metrics in poliomyelitis survivors: putative adaptation to longstanding lower motor neuron degeneration Abstract: <\/span>Background Conclusions: <\/span>Contrary to previous reports, we found no evidence of cerebral grey or white matter degeneration in a cohort of polio survivors using a validated quantitative neuroimaging protocol. The brainstem, corticospinal tracts and the cerebellum exhibit superior integrity in poliomyelitis survivors compared to healthy controls.<\/p>\n Outcome of Research: <\/span>More research required<\/p>\n Comments<\/span> (if any)<\/span>:<\/span> The full text of this paper has been generously made available by the publisher.<\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> Click here to view full text or to download<\/a><\/p>\n Title: <\/span>Late effects of polio: Interviewing general practitioners and health professionals about the need for and the means of promoting continuing professional development. Abstract: <\/span>Background and objectives Conclusions: <\/span>Thousands of Australian and New Zealand polio survivors are experiencing sequelae from past polio infections, many in migrant communities and including women of childbearing age. HCPs need to be aware of LEoP and PPS and incorporate this knowledge into their assessment and management of patients. A lack of awareness of LEoP and PPS, combined with time constraints for CPD, serves to perpetuate a serious gap in clinical knowledge, with potential adverse consequences for patients at risk of not being diagnosed or poorly managed. Outcome of Research: <\/span>Not applicable<\/p>\n Comments<\/span> (if any)<\/span>:<\/span> The full text of this paper has been generously made available by the publisher.<\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> Click here to view full text or to download<\/a><\/p>\n Title: <\/span>Energy conservation, occupational therapy, and the treatment of post-polio sequelae Abstract: <\/span>Individuals experiencing post-polio sequelae (PPS) are usually advised to make significant lifestyle changes to lessen symptoms and prevent further decline in function. These individuals have spent most of their lives equating success with over-achievement and find it difficult to implement such recommendations. As specialists in energy conservation and work simplification, occupational therapists increasingly are being called on to evaluate and treat these patients. Over the past 2 years, an occupational therapy educational program has been developed to educate patients about their condition and about ways to implement lifestyle changes while preserving the ability to do valued activities. This article describes the components of a thorough occupational therapy evaluation and the design and functional outcomes of a successful occupational therapy educational program to treat PPS.<\/p>\n Conclusions: <\/span><\/p>\n Outcome of Research: <\/span><\/p>\n Comments<\/span> (if any)<\/span>:<\/span> <\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> <\/a><\/p>\n Title: <\/span>Neuromuscular function in polio survivors Abstract: <\/span>Although there is no documented, objective evidence that symptomatic post-polio subjects are rapidly losing strength, they have a number of neuromuscular deficits related to a more severe poliomyelitis illness that may explain why they complain of problems with strength, endurance, and local muscle fatigue. Symptomatic post-polio subjects were hospitalized longer during the acute poliomyelitis, recovered more slowly, and had electromyographic evidence of greater loss of anterior horn cells. Additionally, recent assessment demonstrated that they were weaker, had a reduced work capacity, and recovered strength less readily after activity in the quadriceps muscles as compared to asymptomatic subjects. Of great clinical importance, rating of perceived exertion in the muscle during exercise was the same in symptomatic and asymptomatic post-polio and control subjects, indicating that symptomatic subjects have a mechanism to monitor local muscle fatigue that could be used to avoid exhaustion. A study of pacing (interspersing activity with rest breaks) showed that symptomatic subjects had less local muscle fatigue and greater strength recovery when they paced their activity than when they worked at a constant rate to exhaustion. We recommend that post-polio individuals pace their daily activity to avoid excessive fatigue.<\/p>\n Conclusions: <\/span><\/p>\n Outcome of Research: <\/span><\/p>\n Comments<\/span> (if any)<\/span>:<\/span> <\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> Click here to view Abstract<\/a><\/p>\n Title: <\/span>Actual and perceived activity levels in polio survivors and older controls: a longitudinal study Abstract: <\/span>OBJECTIVE: To examine factors associated with daily step activity, perceived activity, maximum walking speed, and walking speed reserve over time in polio survivors and older adults with no history of polio. Conclusions: <\/span>Daily walking activity did not change statistically over the 3-year study period, although perceived activity and the walking speed reserve decreased among polio survivors with PPS. On average, polio survivors appear to function with minimal functional reserve, as their preferred walking speed was close to their maximum speed.<\/p>\n Outcome of Research: <\/span><\/p>\n Comments<\/span> (if any)<\/span>:<\/span> <\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> <\/a><\/p>\n Title: <\/span>Walking in postpoliomyelitis syndrome: the relationships between time\u2010scored tests, walking in daily life and perceived mobility problems Abstract: <\/span>OBJECTIVE: To compare walking test results with walking in daily life, and to investigate the relationships between walking tests, walking activity in daily life, and perceived mobility problems in patients with post-poliomyelitis syndrome. Conclusions: <\/span>Walking in daily life may be more demanding than walking under standardized conditions. Patients with post-poliomyelitis syndrome with the lowest test performance walked less in daily life. Patients do not necessarily match their activity pattern to their perceived mobility problems.
\nAuthor: <\/span>Neilsen NM, Wohlfahrt J, Aaby P, et al.
\nAffiliation: <\/span>Department of Epidemiology, National University, Copenhagen, Denmark
\r\nDepartment of Infectious Diseases, National University, Copenhagen, Denmark
\nJournal: <\/span>International Journal of Cancer
\nCitation: <\/span>(2001). 92, pp.605–608
\nPublication Year and Month: <\/span>2000 11<\/p>\n
\r\n
\r\nInformation on vital status and cancer diagnoses was obtained through linkage with the Danish Civil Registration System and the Danish Cancer Registry, respectively. The ratio of observed number of cancers to the number expected from population-based incidence rates, i.e., the standardized incidence ratio (SIR), served as measure of the relative cancer risk.
\r\n
\r\nOverall, 717 cases of cancer were observed among 5,883 polio patients during 249,084 person-years of follow-up vs. an expected number of 645 (SIR 5 1.11 [95% confidence
\r\ninterval 1.03 to 1.20])). The increased risk was restricted to female polio patients (SIR 5 1.18 [1.07 to 1.30]), among whom the risk was particularly high for breast cancer (SIR 5 1.35 [1.12 to 1.61]) and for skin cancer (SIR 5 1.66 [1.32 to 2.07]). The risk of breast cancer was highest among women with a history of paralytic polio (SIR 5 1.62 [1.24 to 2.10]). The observed number of CNS tumors did not exceed the expected (SIR 5 1.09 [0.72 to 1.60]).
\r\n
\r\nWomen diagnosed with poliomyelitis, in particular paralytic polio, may be at increased risk of breast cancer. There was no association between malignancies of the CNS and poliomyelitis.<\/p>\n
\nCategory: <\/span><\/span><\/p>\n
\nAuthor: <\/span>Martin Ferguson-Pell & Emily Armstrong
\nAffiliation: <\/span>University of Alberta Faculty of Rehabilitation Medicine
\nJournal: <\/span>Archives of Physical Medicine and Rehabilitation
\nCitation: <\/span>Volume 102, Issue 10, Page e10
\r\nhttps:\/\/doi.org\/10.1016\/j.apmr.2021.07.419
\nPublication Year and Month: <\/span>2021 10<\/p>\n
\r\nTo determine the feasibility of a clinic-to-clinic tele-rehabilitation model in rural Alberta.
\r\n
\r\nDesign
\r\nThis pilot study employed a Plan-Do-Study-Act (PDSA) methodology. We focused on 4 clinical areas: Hip & Knee post-arthroplasty follow-up, Vestibular & Balance issues, Severe Shoulder Pain & Instability, and Wheelchair Seating. We co-developed assessment processes with non-physician experts that connected to a general physiotherapist using new technologies. After a series of in-house trials, these assessments were then deployed to 5 rural communities in Alberta. Technologies included Kinetisense Markerless Motion Capture and a telepresence robot. Patients were provided with a minimum of two clinical visits, with follow-up approximately 4 weeks after initial assessment. Experience and outcome measures centered on ICF principles were collected from both patients and clinicians.
\r\n
\r\nSetting
\r\nThe study took place in public and private rehabilitation settings and a primary care facility.
\r\n
\r\nParticipants
\r\nParticipants were selected from a convenience sample by local practitioners. Initial and follow-up assessments for 16 patients in this pilot study were completed.
\r\n
\r\nInterventions
\r\nA novel suite of technologies and processes were developed through close consultation with expert clinicians to enable complex rehabilitation assessments to be conducted remotely.
\r\n
\r\nMain Outcome Measures
\r\nA mix of outcome and experience measures determined the effectiveness of this model. The COPM, and a study-specific Patient Reported Experience Measure, measured patient outcomes. Two study-specific Clinician Reported Experience Measures provided clinician data.
\r\n
\r\nResults
\r\nAcross our 4 modules, 14 out of 16 participants either agreed (3) or strongly agreed (11) that they enjoyed their Tele-Rehab session overall. No participants disagreed, and 2 were neutral. Based on COPM scores, overall patients saw improvements in both performance and satisfaction for their identified goals.The remote clinicians were all confident in the treatment plans prescribed by the hub clinician (n=13, 4 Agree, 9 Strongly Agree). Both hub and remote clinicians had confidence in each other, and all agreed (5) or strongly agreed (18) that the assessments were a success.
\r\n
\r\nKeywords: Telemedicine; Rehabilitation; Technology
\r\n<\/p>\n
\r\nPreliminary results indicate that this is an effective way of delivering care, but additional study is required.<\/p>\n
\nCategory: <\/span><\/span><\/p>\n
\nAuthor: <\/span>Stacey Li Hi Shing, Jasmin Lope, Mary Clare McKenna, Rangariroyashe H. Chipika, Orla Hardiman, Peter Bede
\nAffiliation: <\/span>Computational Neuroimaging Group, Biomedical Sciences Institute, Trinity College Dublin, Ireland
\nJournal: <\/span>NEW - PUT DETAILS IN CITATION FIELD
\nCitation: <\/span>Journal of the Neurological Sciences
\r\n
\r\nStacey Li Hi Shing, Jasmin Lope, Mary Clare McKenna, Rangariroyashe H. Chipika, Orla Hardiman, Peter Bede, Increased cerebral integrity metrics in poliomyelitis survivors: putative adaptation to longstanding lower motor neuron degeneration, Journal of the Neurological Sciences, Volume 424, 2021, 117361, ISSN 0022-510X, https:\/\/doi.org\/10.1016\/j.jns.2021.117361.
\nPublication Year and Month: <\/span>2021 02<\/p>\n
\r\nPost-polio syndrome (PPS) has been traditionally considered a slowly progressive condition that affects poliomyelitis survivors decades after their initial infection. Cerebral changes in poliomyelitis survivors are poorly characterised and the few existing studies are strikingly conflicting.
\r\n
\r\nObjective
\r\nThe overarching aim of this study is the comprehensive characterisation of cerebral grey and white matter alterations in poliomyelitis survivors with reference to healthy- and disease-controls using quantitative imaging metrics.
\r\n
\r\nMethods
\r\nThirty-six poliomyelitis survivors, 88 patients with ALS and 117 healthy individuals were recruited in a prospective, single-centre neuroimaging study using uniform MRI acquisition parameters. All participants underwent standardised clinical assessments, T1-weighted structural and diffusion tensor imaging. Whole-brain and region-of-interest morphometric analyses were undertaken to evaluate patterns of grey matter changes. Tract-based spatial statistics were performed to evaluate diffusivity alterations in a study-specific whiter matter skeleton.
\r\n
\r\nResults
\r\nIn contrast to healthy controls, poliomyelitis survivors exhibited increased grey matter partial volumes in the brainstem, cerebellum and occipital lobe, accompanied by increased FA in the corticospinal tracts, cerebellum, bilateral mesial temporal lobes and inferior frontal tracts. Polio survivors exhibited increased integrity metrics in the same anatomical regions where ALS patients showed degenerative changes.
\r\n
\r\nConclusions
\r\nOur findings indicate considerable cortical and white matter reorganisation in poliomyelitis survivors which may be interpreted as compensatory, adaptive change in response to severe lower motor neuron injury in infancy.
\r\n
\r\nKeywords
\r\nPost-polio syndrome, Motor neuron disease, Neuroimaging, Pathology, Poliomyelitis<\/p>\n
\nCategory: <\/span><\/span><\/p>\n
\nAuthor: <\/span>Petra Quinlan-Turner (1), Phyllis Lau (2), Keith R McVilly (3)
\nAffiliation: <\/span>(1) MBBS, PMETB GP (UK), MPH(Hons), Policy Officer, Surgery Recovery and Reform Branch, Commissioning and System Improvement Division, Victorian Department of Health, Melbourne, Vic. (1 author)
\r\n
\r\n(2) BPharmSci (Hons), GradDip Drug Eval Pharm Sci, PhD, Senior Research Fellow, Department Of General Practice, Faculty of Medicine, Dentistry and Health Science, The University Of Melbourne, Carlton, Vic. (1 author)
\r\n
\r\n(3) PhD, MAPS, FCClP, FIASSIDD, Professor of Disability and Inclusion, School of Social and Political Sciences, The University of Melbourne, Melbourne, Vic. (1 author)
\nJournal: <\/span>NEW - PUT DETAILS IN CITATION FIELD
\nCitation: <\/span>Australian Journal of General Practice, 01 May 2023, 52(5):317-323
\r\nDOI: 10.31128\/ajgp-07-22-6504 PMID: 37149772
\nPublication Year and Month: <\/span>2023 03<\/p>\n
\r\nPolio Australia estimates tens of thousands of polio survivors are experiencing late effects of polio (LEoP), including increased cases among young women of childbearing age in some migrant communities. Because polio has been declared eradicated in Australia, the provision and uptake of education by general practitioners (GPs) and healthcare professionals (HCPs) is minimal. We explored the awareness of LEoP among HCPs and ways to enhance knowledge dissemination to improve clinical practice.
\r\n
\r\nMethod
\r\nA qualitative study was undertaken, informed by a descriptive (transcendental) phenomenological approach. Semistructured interviews were audio recorded, transcribed and analysed inductively, with a conciliation among the research team used to finalise the themes.
\r\n
\r\nResults
\r\nHCPs expressed the importance of learning about LEoP and how this may help build supportive patient-practitioner relationships and contribute to patient outcomes. Factors influencing the uptake of professional development included motivation, possibly stemming from a lack of awareness of LEoP, together with the time and logistical limitations of practice generally.
\r\n
\r\nDiscussion
\r\nOnline learning activities followed by an assessment may be attractive for some HCPs, but peer-based and multidisciplinary continuing professional development activities remain preferred.<\/p>\n
\r\n
\r\nProfessional organisations could combine to develop multidisciplinary peer learning modules on LEoP. Existing online resources, such as the LEoP module on HealthPathways, could be more widely promoted. Organising dedicated symposia, such as that co-hosted by the University of Otago and Polio New Zealand , could also help with the dissemination of knowledge. Importantly, exploring the views of polio survivors and involving them in the co-development and delivery of educational materials could improve the relevance to all stakeholders involved.<\/p>\n
\nCategory: <\/span>Activity Levels<\/span><\/p>\n
\nAuthor: <\/span>Young GR
\nAffiliation: <\/span>Department of Occupational Therapy, Kaiser-Permanente Medical Center, Downey, California 90242
\nJournal: <\/span>Orthopedics
\nCitation: <\/span>Orthopedics. 1991 Nov; 14(11):1233-9
\nPublication Year and Month: <\/span>1991 11<\/p>\n
\nCategory: <\/span>Activity Levels<\/span><\/p>\n
\nAuthor: <\/span>Agre JC, Rodriquez AA
\nAffiliation: <\/span>Department of Rehabilitation Medicine, University of Wisconsin - Madison Medical School 53792
\nJournal: <\/span>Orthopedics
\nCitation: <\/span>Orthopedics. 1991 Dec; 14(12):1343-7
\nPublication Year and Month: <\/span>1991 12<\/p>\n
\nCategory: <\/span>Activity Levels<\/span><\/p>\n
\nAuthor: <\/span>Klein MG, Braitman LE, Costello R, Keenan MA, Esquenazi A
\nAffiliation: <\/span>Moss Rehabilitation Research Institute, Philadelphia, PA; Thomas Jefferson University, Philadelphia 19141, USA – mklein@einstein.edu
\nJournal: <\/span>Archives of Physical Medicine and Rehabilitation
\nCitation: <\/span>Arch Phys Med Rehabil. 2008 Feb; 89(2):297-303
\nPublication Year and Month: <\/span>2008 02<\/p>\n
\n
\nDESIGN: Longitudinal study.
\n
\nSETTING: A research clinic and the community.
\n
\nPARTICIPANTS: Polio survivors (n=96; 65 in postpolio syndrome [PPS] group, 31 in non-PPS group) and older adults (n=112) with no history of polio.
\n
\nINTERVENTIONS: Not applicable.
\n
\nMAIN OUTCOME MEASURES: Daily step activity, perceived activity, maximum walking speed, and walking speed reserve.
\n
\nRESULTS: Results showed decreases in perceived activity over time in the PPS group. However, there was no change in average daily walking activity. Overall, polio survivors walk less and have a smaller walking speed reserve than controls. Knee strength was positively associated with maximum walking speed and walking speed reserve in all groups. Weight and age were associated with daily step activity in controls but not polio survivors.<\/p>\n
\nCategory: <\/span>Activity Levels<\/span><\/p>\n
\nAuthor: <\/span>Horemans HL, Bussmann JB, Beelen A, Stam HJ, Nollet F
\nAffiliation: <\/span>Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands - h.l.d.horemans@erasmusmc.nl
\nJournal: <\/span>Journal of Rehabilitation Medicine
\nCitation: <\/span>J Rehabil Med. 2005 May;37(3):142-6.
\nPublication Year and Month: <\/span>2005 05<\/p>\n
\n
\nSUBJECTS: Twenty-four ambulant patients with post-poliomyelitis syndrome.
\n
\nMETHODS: Walking tests were performed at self-preferred and maximal speed. Walking activity was measured with an ambulatory activity monitor. Heart rate, step cadence and walking speed in the test and in daily life were compared. Walking speed in daily life was represented by the intensity of walking. Perceived mobility problems were assessed with the Nottingham Health Profile.
\n
\nRESULTS: Heart rate during walking was lower in the test at self-preferred speed than in daily life (mean difference: 11.3+\/-10.4; p=0.001). Self-preferred walking speed in the test and in daily life correlated significantly (r=0.55; p=0.04). In a sub-group with a test performance below the median value, test performance correlated significantly with walking activity. No significant correlation was found between perceived mobility problems and walking activity.<\/p>\n
\n<\/p>\n