{"id":13265,"date":"2015-03-28T11:02:36","date_gmt":"2015-03-28T00:02:36","guid":{"rendered":"http:\/\/www.poliohealth.org.au\/?page_id=13265"},"modified":"2017-09-15T14:58:53","modified_gmt":"2017-09-15T04:58:53","slug":"post-polio-research-papers-sorted-by-author","status":"publish","type":"page","link":"https:\/\/www.poliohealth.org.au\/research-sorted-by-author\/","title":{"rendered":"Post-Polio Research Papers – Sorted by Author"},"content":{"rendered":"
Title: <\/span>Plasma CHI3L1 in Amyotrophic Lateral Sclerosis: A Potential Differential Diagnostic Biomarker Abstract: <\/span>Background: Motor neuron diseases (MNDs) are fatal neurodegenerative diseases. Biomarkers could help with defining patients’ prognoses and stratifications. Besides neurofilaments, chitinases are a promising family of possible biomarkers which correlate with neuroinflammatory status. We evaluated the plasmatic levels of CHI3L1 in MNDs, MND mimics, and healthy controls (HCs). Conclusions: <\/span>The measurement of the plasmatic levels of CHI3L1 could be useful in the differential diagnosis between MNDs and MND mimics. This is an important issue, since the early diagnosis of an MND is a determinant in the early starting of neuroprotective therapy and in clinical trial recruitment. Outcome of Research: <\/span>More research required<\/p>\n Comments<\/span> (if any)<\/span>:<\/span> The full text of this paper has been generously made available by the publisher.<\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> Click here to view full text or to download<\/a><\/p>\n Title: <\/span>Functional walking capacity of subjects with paralyzed knee extensors while walking with an SCO in locked vs unlocked mode Abstract: <\/span>People with a paresis or paralysis of the knee extensors depend on knee-ankle-foot orthoses (KAFOs) to restore walking ability. Unlike locked KAFOs whose orthotic Conclusions: <\/span>Compared to the unlocked condition, the locked mode imposed a clinically meaningful restriction to the functional walking capacity on the subjects. Therefore, fitting Outcome of Research: <\/span>More research required<\/p>\n Comments<\/span> (if any)<\/span>:<\/span> <\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> Click here to view full text or to download<\/a><\/p>\n Title: <\/span>Restless legs syndrome and post polio syndrome: a case-control study Abstract: <\/span>Background and purpose Conclusions: <\/span>Our findings demonstrate a high prevalence of RLS in PPS, and that RLS occurrence may significantly influence the HRQoL and fatigue of PPS patients. A hypothetical link between neuroanatomical and inflammatory mechanisms in RLS and PPS is suggested.<\/p>\n Outcome of Research: <\/span>More research required<\/p>\n Comments<\/span> (if any)<\/span>:<\/span> Paid subscription required to view or download full text.<\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> Click here to view Abstract<\/a><\/p>\n Title: <\/span>Early and late losses of motor units after poliomyelitis Abstract: <\/span>Motor unit number estimation was employed to assess muscle innervation in 76 patients with prior poliomyelitis. Of the 68 patients who were < 70 years of age, new musculoskeletal symptoms had appeared in all but four; the mean latent interval was 38.0 +\/- 10.1 years. As expected, there was a high incidence of muscles exhibiting denervation in previously affected limbs (87%). However, the incidence in supposedly unaffected limbs was also high (65%). Significant differences in the degree of denervation were found between muscles of the same hands and feet. Judged on the basis of their potential amplitudes, the surviving motor units in partially denervated muscles tended to be enlarged. The enlargement was proportional to the extent of the denervation and was comparable to that found in amyotrophic lateral sclerosis. In some muscles, possibly those innervated by failing motor neurons, motor-unit enlargement was not present. Needle examination confirmed the high incidences of denervation in affected and allegedly unaffected limbs. Of the 188 muscles with EMG features of chronic denervation, only nine exhibited fibrillations or positive sharp waves (4.8%). Ninety-five muscles of 18 patients were studied a second time after an interval of 2 years. Overall, there was a 13.4% reduction in motor-unit number and a 18.4% diminution in M-wave amplitude (P < 0.001). The rate of motor-unit loss was twice that occurring in healthy subjects aged > 60 years. Analysis of individual patients indicated that some were deteriorating more rapidly than others. These studies confirm that denervation progresses in patients with prior poliomyelitis in both clinically affected and unaffected muscles, and indicate that this progression is more rapid than that occurring in normal ageing. Conclusions: <\/span>In conclusion, MUNE may be said to have fulfilled expectations in throwing new light on the extent of muscle denervation in poliomyelitis, and on the adaptive properties and subsequent loss of surviving motor units. Thus, motor unit loss following the initial infection was shown to be more severe and more widespread than previously supposed. Axonal sprouting is as vigorous as in amyotrophic lateral sclerosis, but is not seen in some motor units, possibly because of impending motor neuron death. Indeed, in some patients with post-polio syndrome, further losses of motor units can be demonstrated.<\/p>\n Outcome of Research: <\/span>More research required<\/p>\n Comments<\/span> (if any)<\/span>:<\/span> The full text of this paper has been generously made available by the publisher.<\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> Click here to view full text or to download<\/a><\/p>\n Title: <\/span>Sleep disordered breathing in adult with polio sequelae: A case control study of predictive factors Abstract: <\/span>Introduction\/Background Conclusions: <\/span>Despite there was an increased ratio of SDB in patients with bulbar and trunk involvement, only scoliosis seems to specifically increase the risk of SDB occurrence among polio survivors. In those patients, symptoms suggestive of SDB should be searched for systematically, especially in case of trunk deformities.<\/p>\n Outcome of Research: <\/span>More research required<\/p>\n Comments<\/span> (if any)<\/span>:<\/span> <\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> Click here for preview<\/a><\/p>\n Title: <\/span>Risk assessment and prognostic in patients with post polio syndrome according to systematic tongue analysis adapted from traditional Chinese medicine Abstract: <\/span>Background: The tongue is used in traditional Chinese medicine for prognostic assessment. Muscle weakness, fatigue, pain and other symptoms occur with great variability in post polio syndrome (PPS). Conclusions: <\/span>Conclusion: STA identified, through the coating, a patient with worsening risk confirmed; and a patient with association of severe chronic diseases (her follow-up will be analyzed in a later work). <\/p>\n Outcome of Research: <\/span>More research required<\/p>\n Comments<\/span> (if any)<\/span>:<\/span> The full text of this paper has been generously made available by the publisher.<\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> Click here to view full text or to download<\/a><\/p>\n Title: <\/span>Clinical neurological and tongue inspection according to Traditional Chinese Medicine (TCM) – evaluation of post polio syndrome patients Abstract: <\/span>Objective: To describe tongue characteristics of PPS patients relating to neurology. Conclusions: <\/span>Conclusion: The frequency of enlarged size associated to minor normal characteristics in OF and in tongue coating suggests that the group has a less marked impairment within the natural history of PPS.<\/p>\n Outcome of Research: <\/span>More research required<\/p>\n Comments<\/span> (if any)<\/span>:<\/span> The full text of this paper has been generously made available by the publisher.<\/p>\n Link to Full Paper<\/span> (if available)<\/span>:<\/span> Click here to view full text or to download<\/a><\/p>\n Title: <\/span>Sleep-disordered breathing in neuromuscular disease Abstract: <\/span>Sleep-disordered breathing in neuromuscular diseases is due to an exaggerated reduction in lung volumes during supine sleep, a compromised physiologic adaptation to sleep, and specific features of the diseases that may promote upper airway collapse or heart failure. The normal decrease in the rib cage contribution to the tidal volume during phasic REM sleep becomes a critical vulnerability, resulting in saw-tooth oxygen desaturation possibly representing the earliest manifestation of respiratory muscle weakness. Hypoventilation can occur in REM sleep and progress into non-REM sleep, with continuous desaturation and hypercarbia. Specific characteristics of neuromuscular disorders, such as pharyngeal neuropathy or weakness, macroglossia, bulbar manifestations, or low lung volumes, predispose patients to the development of obstructive events. Central sleep-disordered breathing can occur with associated cardiomyopathy (e.g., dystrophies) or from instability in the control of breathing due to diaphragm weakness. Mitigating factors such as recruitment of accessory respiratory muscles, reduction in REM sleep, and loss of normal REM atonia in some individuals may partially protect against sleep-disordered breathing. Noninvasive ventilation, a standard-of-care management option for sleep-disordered breathing, can itself trigger specific sleep-disordered breathing events including air leaks, patient-ventilator asynchrony, central sleep apnea, and glottic closure. These events increase arousals, reduce adherence, and impair sleep architecture. Polysomnography plays an important role in addressing pitfalls in the diagnosis of sleep-disordered breathing in neuromuscular diseases, identifying sleep-disordered breathing triggered by noninvasive ventilation, and optimizing noninvasive ventilation settings.<\/p>\n Conclusions: <\/span><\/p>\n
\nAuthor: <\/span> Alessandro Bombaci*, Umberto Manera, Giovanni De Marco, Federico Casale, Paolina Salamone, Giuseppe Fuda, Giulia Marchese, Barbara Iazzolino, Laura Peotta, Cristina Moglia, Andrea Calvo and Adriano Chiò<\/span>
\nAffiliation: <\/span>“Rita Levi Montalcini” Department of Neuroscience, University of Turin, 10126 Turin, Italy
\nJournal: <\/span>NEW - PUT DETAILS IN CITATION FIELD
\nCitation: <\/span>J. Clin. Med. 2023, 12(6), 2367; https:\/\/doi.org\/10.3390\/jcm12062367
\nPublication Year and Month: <\/span>2023 03<\/p>\n
\r\n
\r\nMethods: We used a sandwich ELISA to quantify the CHI3L1 in plasma samples from 44 MND patients, 7 hereditary spastic paraplegia (HSP) patients, 9 MND mimics, and 19 HCs. We also collected a ALSFRSr scale, MRC scale, spirometry, mutational status, progression rate (PR), blood sampling, and neuropsychological evaluation.
\r\n
\r\nResults: The plasma levels of the CHI3L1 were different among groups (p = 0.005). Particularly, the MND mimics showed higher CHI3L1 levels compared with the MND patients and HCs. The CHI3L1 levels did not differ among PMA, PLS, and ALS, and we did not find a correlation among the CHI3L1 levels and clinical scores, spirometry parameters, PR, and neuropsychological features. Of note, the red blood cell count and haemoglobin was correlated with the CHI3L1 levels (respectively, p < 0.001, r = 0.63; p = 0.022, and r = 0.52).
\r\n
\r\nConclusions: The CHI3L1 plasma levels were increased in the MND mimics cohort compared with MNDs group. The increase of CHI3L1 in neuroinflammatory processes could explain our findings. We confirmed that the CHI3L1 plasma levels did not allow for differentiation between ALS and HCs, nor were they correlated with neuropsychological impairment.
\r\n
\r\nKeywords: biomarker; chitinases; cognitive impairment; differential diagnosis; early diagnosis; MND mimics; red blood cells<\/p>\n
\r\nFurther multicentre and longitudinal studies on a larger patient cohort, testing alongside other fluid biomarkers, are needed to better explain the role of CHI3L1 in the diagnosis and prognosis of MNDs and, also, of MND mimics.<\/p>\n
\nCategory: <\/span>Orthoses<\/p>\n
\nAuthor: <\/span> Sarah Schroder, Eva Probsting, Thomas Schmalz, Andreas Kannenberg, Hartmut Stinus<\/span>
\nAffiliation: <\/span>Ottobock SE & Co. KGaA, Duderstadt, Germany
\nJournal: <\/span>Physical Medicine and Rehabilitation Research (PM&R)
\nCitation: <\/span>DOI: 10.15761\/PMRR.1000168
\nPublication Year and Month: <\/span>2018 <\/p>\n
\r\nknee joints are only unlocked for sitting down, stance control orthoses (SCOs) may utilize various mechanisms to lock the orthotic knee joint during the stance phase
\r\nand unlock it for a free swing phase. Thus far, all studies comparing SCOs to locked KAFOs have only used laboratory-based measures, but no clinical performance
\r\nmeasures commonly used in rehabilitation medicine. Therefore, the aim of this study was to investigate functional walking capacity using the 6-minute walk test
\r\n(6MWT), combined with objective 3D gait measurements, in established SCO users when using the orthosis in the unlocked and locked mode, respectively. In
\r\naddition, satisfaction with the SCO was surveyed using the QUEST questionnaire. A total of eight subjects participated in this study. The results show that in the
\r\nlocked condition, subjects walked a significantly shorter distance (284.4±53.0 m vs. 316.9±59.6 m, p=.04) in the 6MWT than in the unlocked condition. Gait was
\r\nmore physiological in the unlocked mode with a mean knee flexion angle during swing of 57°±15° vs. full extension in the locked mode. QUEST scores showed a
\r\nhigh overall satisfaction with the E-MAG Active SCO.<\/p>\n
\r\nof an SCO may be considered beneficial in individuals dependent on a KAFO to improve their functional walking capacity. <\/p>\n
\nCategory: <\/span>Late Effects of Polio, Restless Legs Syndrome<\/p>\n
\nAuthor: <\/span>A Romigi, M Pierantozzi, F Placidi, E Evangelista, M Albanese, C Liguori, M Nazzaro, B U Risina, V Simonelli, F Izzi, N B Mercuri, M T Desiato<\/span>
\nAffiliation: <\/span>Neurophysiopathology Unit, Sleep Medicine Centre, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; IRCCS Neuromed Via Atinense 18, Pozzilli (IS), Italy.
\nJournal: <\/span>European Journal of Neurology
\nCitation: <\/span>22(3):472-8.
\r\ndoi: 10.1111\/ene.12593.
\nPublication Year and Month: <\/span>2015 03<\/p>\n
\r\nThe aim was to investigate the prevalence of restless legs syndrome (RLS), fatigue and daytime sleepiness in a large cohort of patients affected by post polio syndrome (PPS) and their impact on patient health-related quality of life (HRQoL) compared with healthy subjects.
\r\n
\r\nMethods
\r\nPPS patients were evaluated by means of the Stanford Sleepiness Scale and the Fatigue Severity Scale (FSS). The Short Form Health Survey (SF-36) questionnaire was utilized to assess HRQoL in PPS. RLS was diagnosed when standard criteria were met. Age and sex matched healthy controls were recruited amongst spouses or friends of PPS subjects.
\r\n
\r\nResults
\r\nA total of 66 PPS patients and 80 healthy controls were enrolled in the study. A significantly higher prevalence of RLS (P < 0.0005; odds ratio 21.5; 95% confidence interval 8.17–57) was found in PPS patients (PPS\/RLS+ 63.6%) than in healthy controls (7.5%). The FSS score was higher in PPS\/RLS+ than in PPS\/RLS− patients (P = 0.03). A significant decrease of SF-36 scores, including the physical function (P = 0.001), physical role (P = 0.0001) and bodily pain (P = 0.03) domains, was found in PPS\/RLS+ versus PPS\/RLS− patients. Finally, it was found that PPS\/RLS+ showed a significant correlation between International Restless Legs Scale score and FSS (P < 0.0001), as well as between International Restless Legs Scale score and most of the SF-36 items (physical role P = 0.0018, general health P = 0.0009, vitality P = 0.0022, social functioning P = 0.002, role emotional P = 0.0019, and mental health P = 0.0003).<\/p>\n
\nCategory: <\/span>Late Effects of Polio, Post-Polio Motor Unit<\/p>\n
\nAuthor: <\/span>A. J. McComas (1), C. Quartly (1) and R. C. Griggs (2)<\/span>
\nAffiliation: <\/span>(1) Department of Medicine, McMaster University, Hamilton, Canada
\r\n
\r\n(2) Department of Neurology, University of Medicine (Neurology), Health Sciences Centre (4U1),
\r\nRochester, New York, USA
\nJournal: <\/span>NEW - PUT DETAILS IN CITATION FIELD
\nCitation: <\/span>Brain (1997), 120, 1415–1421
\nPublication Year and Month: <\/span>1997 08<\/p>\n
\r\n
\r\nKeywords: poliomyelitis; motor units; EMG<\/p>\n
\nCategory: <\/span>Respiratory Complications and Management<\/p>\n
\nAuthor: <\/span>A.Leotard, A.Pages, M.Salga, G.Genet, J.Levy, M.A.Quera-Salva, F.Genet<\/span>
\nAffiliation: <\/span>Hopital R.-Poincaré, Sleep unit, Garches, France
\r\n
\r\nHopital R.-Poincaré, Department of Physical Medicine and Rehabilitation, Garches, France
\nJournal: <\/span>Annals of Physical and Rehabilitation Medicine
\nCitation: <\/span>Volume 61, Supplement, July 2018, Page e72
\r\n
\nPublication Year and Month: <\/span>2018 07<\/p>\n
\r\nEstimates of sleep disorder breathing (SDB) prevalence are higher in patients with polio sequelae than in general population, ranging from 50% to 65%. No specific predictive factors have been described in our knowledge. The aim of this study was to identify SDB predictive factors among polio survivors.
\r\n
\r\nMaterial and method
\r\nA case control study including patients with polio sequelae with confirmed SDB (apnea hypopnea index (AHI) ≥ 5; n = 38) compared to polio patients with AHI ≤ 5 or negative Berlin questionnaire (n = 114). Matching criteria were: sex, age at evaluation, and body mass index (BMI). For each patient, age at acute polio, bulbar, trunk, and lower limbs involvement, scoliosis, current walking abilities and history of arthrodesis, brace or iron lung were assessed using preexisting database and medical charts. SDB symptoms, Berlin questionnaire and AHI using polysomnographic reports were also assessed retrospectively.
\r\n
\r\nResults
\r\nAmong the 362 polio patients from our systematic database 152 (38 cases and 114 controls) were matched for comparison. SDB ratio was significantly higher in patients with bulbar involvement at acute polio (100% vs. 22.5%), trunk involvement at acute polio (41.9% vs. 18.4%), bulbar involvement at evaluation (100% vs. 23%), scoliosis (38.6% vs. 13.8%) and non-walking patients (50% vs. 22.5%) compared with polio controls. Multivariate analysis only shown scoliosis to be associated with SDB in those patients (OR = 2.72 (95% CI: 1.10–6.95); P = 0.03).<\/p>\n
\nCategory: <\/span>Complementary Therapies<\/p>\n
\nAuthor: <\/span>Abe, G.C., Ramos, P.E. da Silva, B.L., Mello, C.A.D.S., Quadros, A.A.J., Oliveira, A.S.B.<\/span>
\nAffiliation: <\/span>Federal University of São Paulo, Neurology and Neurosurgery, São Paulo, Brazil
\nJournal: <\/span>Journal of the Neurological Sciences
\nCitation: <\/span>Volume 381, Supplement, 15 October 2017, Pages 1138-1139
\r\n
\nPublication Year and Month: <\/span>2017 10<\/p>\n
\r\n
\r\nObjective: Identify risk patients in a group with PPS through observation of tongue coating with systematic tongue analysis (STA).<\/p>\n
\nCategory: <\/span>Complementary Therapies<\/p>\n
\nAuthor: <\/span>Abe, G.C., Ramos, P.E., da Silva, B.L., Quadros, A.J., Oliveira, A.S.B.<\/span>
\nAffiliation: <\/span>Universidade Federal de São Paulo, Neurologia e Neurocirurgia, São Paulo - SP, Brazil
\nJournal: <\/span>Journal of the Neurological Sciences
\nCitation: <\/span>Volume 381, Supplement, 15 October 2017, Pages 199-200
\r\n
\nPublication Year and Month: <\/span>2017 10<\/p>\n
\r\n
\r\nRESULTS
\r\n89 individuals were evaluated within a 12 month period, 61 (68,5%) females, 28(31,5%)males, aged from 32–57 years old (mean = 46). The most frequent characteristics were: decreased moisture (52.5%); thick whitish coating (60.7%); red color (46,1%), and normal movement (49.4%). The enlarged size (40.4%) prevailed over the small\/thin size (15.7%). The presence of “other findings” (OF) was over 70%.<\/p>\n
\nCategory: <\/span>Respiratory Complications and Management<\/p>\n
\nAuthor: <\/span>Aboussouan LS<\/span>
\nAffiliation: <\/span>Respiratory Institute, Cleveland Clinic, Cleveland, Ohio
\nJournal: <\/span>American Journal of Respiratory and Critical Care Medicine
\nCitation: <\/span>Am J Respir Crit Care Med. 2015 May 1;191(9):979-89. doi: 10.1164\/rccm.201412-2224CI
\nPublication Year and Month: <\/span>2015 05<\/p>\n